UBC13/YDR092W Summary

UBC13 BASIC INFORMATION

Standard Name	UBC13
Systematic Name	YDR092W
Feature Type	ORF, Verified
Description	Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus (1, 2, 3)
Name Description	UBiquitin-Conjugating

GO Annotations	All UBC13 GO evidence and references
	View Computational GO annotations for UBC13
Molecular Function
Manually curated	contributes_to ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	free ubiquitin chain polymerization (IDA) postreplication repair (IGI, IMP) protein monoubiquitination (TAS) protein polyubiquitination (IDA)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA) ubiquitin conjugating enzyme complex (IPI)

Mutant Phenotype	All UBC13 Phenotype details and references
Classical genetics
null	mutation frequency: increased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine: decreased resistance to selenomethionine: decreased
Large-scale survey
null	UV resistance: decreased bud morphology: abnormal inositols excretion: increased resistance to methyl methanesulfonate: decreased viable

Interactions	UBC13 All interactions details and references
	80 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 4 Co-crystal Structure: 2 Co-localization: 1 Co-purification: 3 PCA: 6 Reconstituted Complex: 6 Two-hybrid: 9
Genetic Interactions	Phenotypic Enhancement: 29 Phenotypic Suppression: 2 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 2

Sequence Information

ChrIV:629874 to 630603 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..30	629874..629903	2008-06-05	1996-07-31
Intron	31..298	629904..630171	2008-06-05	1996-07-31
CDS	299..730	630172..630603	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002499

UBC13 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for UBC13

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for UBC13]

1)	Ulrich HD and Jentsch S (2000) Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. EMBO J 19(13):3388-97
2)	Brusky J, et al. (2000) UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae. Curr Genet 37(3):168-74
3)	Hofmann RM and Pickart CM (1999) Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96(5):645-53

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