Standard Name	UBC13
Systematic Name	YDR092W
Feature Type	ORF, Verified
Description	Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus (1, 2, 3)
Name Description	UBiquitin-Conjugating

Chromosomal Location	ChrIV:629876 to 630605 | ORF Map | GBrowse

	View Computational GO annotations for UBC13
Molecular Function
Manually curated	contributes_to ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	free ubiquitin chain polymerization (IDA) postreplication repair (IGI, IMP) protein monoubiquitination (TAS) protein polyubiquitination (IDA)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA) ubiquitin conjugating enzyme complex (IPI)

Classical genetics
null	mutation frequency: increased Matalpha1p accumulation: increased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine: decreased resistance to selenomethionine: decreased resistance to methyl methanesulfonate: decreased
Large-scale survey
null	UV resistance: decreased bud morphology: abnormal inositol excretion: increased competitive fitness: increased resistance to fluconazole: decreased resistance to fenpropimorph: decreased resistance to caffeine: decreased resistance to bleomycin: decreased resistance to methyl methanesulfonate: decreased resistance to tirapazamine: decreased resistance to camptothecin: increased resistance to hydrogen chloride: increased resistance to acetic acid: increased resistance to (S)-lactic acid: increased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	185 total interaction(s) for 129 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 2 Co-crystal Structure: 2 Co-localization: 1 Co-purification: 3 PCA: 7 Reconstituted Complex: 8 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 93 Phenotypic Enhancement: 12 Phenotypic Suppression: 3 Positive Genetic: 10 Synthetic Growth Defect: 10 Synthetic Lethality: 3 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:629876 to 630605 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..30 629876..629905 2011-02-03 1996-07-31 Intron 31..298 629906..630173 2011-02-03 1996-07-31 CDS 299..730 630174..630605 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (31 - 298)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002499