UBC1/YDR177W Summary Help

Standard Name UBC1 1
Systematic Name YDR177W
Feature Type ORF, Verified
Description Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex (APC); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress key E2 partner with Ubc4p for the anaphase-promoting complex (APC) (1, 2, 3, 4, 5, 6)
Name Description UBiquitin-Conjugating 1
Chromosomal Location
ChrIV:816878 to 817525 | ORF Map | GBrowse
Gene Ontology Annotations All UBC1 GO evidence and references
  View Computational GO annotations for UBC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
Large-scale survey
reduction of function
59 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Biochemical Activity: 3
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 13
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 6
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 6

Expression Summary
Length (a.a.) 215
Molecular Weight (Da) 24,178
Isoelectric Point (pI) 4.97
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:816878 to 817525 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..648 816878..817525 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002584
References cited on this page View Complete Literature Guide for UBC1
1) Seufert W, et al.  (1990) UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation. EMBO J 9(13):4535-41
2) Seufert W and Jentsch S  (1991) Yeast ubiquitin-conjugating enzymes involved in selective protein degradation are essential for cell viability. Acta Biol Hung 42(1-3):27-37
3) Friedlander R, et al.  (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84
4) Shieh HL, et al.  (2001) Biochemical analysis of fructose-1,6-bisphosphatase import into vacuole import and degradation vesicles reveals a role for UBC1 in vesicle biogenesis. J Biol Chem 276(13):10398-406
5) Rodrigo-Brenni MC and Morgan DO  (2007) Sequential E2s Drive Polyubiquitin Chain Assembly on APC Targets. Cell 130(1):127-39
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76