UBA1/YKL210W Summary Help

Standard Name UBA1 1
Systematic Name YKL210W
Feature Type ORF, Verified
Description Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress (1, 2)
Name Description UBiquitin Activating 1
Chromosomal Location
ChrXI:39163 to 42237 | ORF Map | GBrowse
Gbrowse
Genetic position: -153.3 cM
Gene Ontology Annotations All UBA1 GO evidence and references
  View Computational GO annotations for UBA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
conditional
repressible
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
78 total interaction(s) for 58 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 37
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3
  • Biochemical Activity: 12
  • Co-crystal Structure: 1
  • Co-purification: 1
  • PCA: 3
  • Reconstituted Complex: 11

Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,024
Molecular Weight (Da) 114,265
Isoelectric Point (pI) 4.81
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:39163 to 42237 | ORF Map | GBrowse
SGD ORF map
Genetic position: -153.3 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3075 39163..42237 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001693
References cited on this page View Complete Literature Guide for UBA1
1) McGrath JP, et al.  (1991) UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme. EMBO J 10(1):227-36
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76