Standard Name	UAF30 1
Systematic Name	YOR295W
Feature Type	ORF, Verified
Description	Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication (1, 2)
Name Description	Upstream Activation Factor subunit 1

Chromosomal Location	ChrXV:869208 to 869894 | ORF Map | GBrowse

	View Computational GO annotations for UAF30
Molecular Function
Manually curated	RNA polymerase I upstream control element sequence-specific DNA binding (IDA) contributes_to RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity (IMP)
Biological Process
Manually curated	chromatin organization (IMP) transcription of nuclear large rRNA transcript from RNA polymerase I promoter (IMP)
Cellular Component
Manually curated	nucleolus (IDA) RNA polymerase I upstream activating factor complex (IDA)

Classical genetics
null	resistance to selenium(2+): decreased vegetative growth: decreased rate
Large-scale survey
null	bud morphology: abnormal cell cycle progression in G1 phase: increased duration cell size: decreased proton accumulation: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate heat sensitivity: increased inviable resistance to arsenite(3-): decreased resistance to tirapazamine: decreased resistance to doxorubicin: decreased resistance to amiodarone: decreased resistance to citric acid: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to paromomycin: decreased resistance to streptomycin: decreased resistance to caffeine: decreased resistance to acetic acid: decreased resistance to pentachlorophenol: decreased resistance to methyl methanesulfonate: decreased stress resistance: increased toxin resistance: increased toxin resistance: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	72 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Biochemical Activity: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 4 Phenotypic Suppression: 10 Positive Genetic: 35 Synthetic Growth Defect: 5 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:869208 to 869894 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..687 869208..869894 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005821