Standard Name	TUS1 1
Systematic Name	YLR425W
Alias	SOP10
Feature Type	ORF, Verified
Description	Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate (1, 2, 3, 4)
Name Description	TOR Unique function Suppressor 1

Chromosomal Location	ChrXII:982894 to 986817 | ORF Map | GBrowse

	View Computational GO annotations for TUS1
Molecular Function
Manually curated	Rho guanyl-nucleotide exchange factor activity (IDA)
Biological Process
Manually curated	fungal-type cell wall organization (IGI, IMP) signal transduction (IGI, IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) incipient cellular bud site (IDA)

Classical genetics
null	metal resistance: decreased resistance to arsenate ion: decreased
Large-scale survey
null	cell cycle progression in G1 phase: increased duration chitin deposition: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased ionic stress resistance: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to Calcofluor White: decreased resistance to sirolimus: decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to elesclomol-Cu: decreased respiratory growth: decreased rate stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	85 total interaction(s) for 60 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Biochemical Activity: 2 Co-localization: 1 PCA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 8 Phenotypic Suppression: 9 Positive Genetic: 1 Synthetic Growth Defect: 9 Synthetic Lethality: 40 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:982894 to 986817 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3924 982894..986817 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004417