TSC3/YBR058C-A Summary Help

Standard Name TSC3 1
Systematic Name YBR058C-A
Feature Type ORF, Verified
Description Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase (1, 2)
Name Description Temperature-sensitive Suppressors of Csg2 mutants 3
Chromosomal Location
ChrII:356566 to 356324 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TSC3 GO evidence and references
  View Computational GO annotations for TSC3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
conditional
null
Large-scale survey
conditional
null
Resources
90 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 56
  • Phenotypic Enhancement: 1
  • Positive Genetic: 17
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 80
Molecular Weight (Da) 9,579
Isoelectric Point (pI) 9.24
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:356566 to 356324 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2000-06-19
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..243 356566..356324 2011-02-03 2000-06-19
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007521
References cited on this page View Complete Literature Guide for TSC3
1) Gable K, et al.  (2000) Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. J Biol Chem 275(11):7597-603
2) Monaghan E, et al.  (2002) Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae. Yeast 19(8):659-70
3) Beeler T, et al.  (1998) The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. J Biol Chem 273(46):30688-94