TRS130/YMR218C Summary Help

Standard Name TRS130 1
Systematic Name YMR218C
Feature Type ORF, Verified
Description Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic (1, 2, 3, 4)
Name Description TRapp Subunit 1
Chromosomal Location
ChrXIII:706887 to 703579 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TRS130 GO evidence and references
  View Computational GO annotations for TRS130
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
reduction of function
Resources
82 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-Western: 14
  • Reconstituted Complex: 2
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 13
  • Negative Genetic: 8
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 4
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,102
Molecular Weight (Da) 128,129
Isoelectric Point (pI) 5.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:706887 to 703579 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3309 706887..703579 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004831
References cited on this page View Complete Literature Guide for TRS130
1) Sacher M, et al.  (2000) Identification and characterization of five new subunits of TRAPP. Eur J Cell Biol 79(2):71-80
2) Sacher M, et al.  (2001) TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport. Mol Cell 7(2):433-42
3) Yamamoto K and Jigami Y  (2002) Mutation of TRS130, which encodes a component of the TRAPP II complex, activates transcription of OCH1 in Saccharomyces cerevisiae. Curr Genet 42(2):85-93
4) Zou S, et al.  (2013) Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae. Traffic 14(2):233-46