Standard Name	TRS130 1
Systematic Name	YMR218C
Feature Type	ORF, Verified
Description	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy (1, 2, 3, 4)
Name Description	TRapp Subunit 1

Chromosomal Location	ChrXIII:706887 to 703579 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TRS130
Molecular Function
Manually curated	contributes_to Rab guanyl-nucleotide exchange factor activity (IGI, IMP, IPI)
Biological Process
Manually curated	CVT pathway (IMP) early endosome to Golgi transport (IMP) intra-Golgi vesicle-mediated transport (IMP) macroautophagy (IMP) regulation of Rab GTPase activity (IMP)
Cellular Component
Manually curated	early endosome (IDA) trans-Golgi network (IDA) TRAPP complex (IDA)

Classical genetics
conditional	Golgi morphology: abnormal autophagy: absent colony sectoring: increased endomembrane system morphology: abnormal heat sensitivity: increased protein secretion: absent invertase secretion: decreased invertase secretion: absent carboxypeptidase Y (CPY) transport: decreased GFP-Snc1p distribution: abnormal Chs3p-GFP distribution: abnormal Ypt1p distribution: abnormal Ypt31p distribution: abnormal vacuolar transport: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable resistance to ciclopirox olamine: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	73 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-Western: 14 Reconstituted Complex: 2 Two-hybrid: 8
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 13 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Synthetic Growth Defect: 5 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:706887 to 703579 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3309 706887..703579 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004831