TRP3/YKL211C Summary

TRP3 BASIC INFORMATION

Standard Name	TRP3 1
Systematic Name	YKL211C
Feature Type	ORF, Verified
Description	Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p (2, 3, 4, 5)
Name Description	TRyPtophan requiring

GO Annotations	All TRP3 GO evidence and references
	View Computational GO annotations for TRP3
Molecular Function
Manually curated	contributes_to anthranilate synthase activity (IGI) indole-3-glycerol-phosphate synthase activity (IGI, IMP, ISS)
Biological Process
Manually curated	tryptophan biosynthetic process (IMP)
Cellular Component
Manually curated	anthranilate synthase complex (IPI)
High-throughput	cytoplasm (IDA)

Pathways	pathways of chorismate superpathway of phenylalanine, tyrosine and tryptophan biosynthesis tryptophan biosynthesis

Mutant Phenotype	All TRP3 Phenotype details and references
Classical genetics
null	resistance to 2-phenylethanol: decreased resistance to 5-fluoroanthranilic acid: increased
unspecified	auxotrophy
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased heat sensitivity: increased oxidative stress resistance: decreased resistance to miconazole: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to ethanol: decreased resistance to methyl methanesulfonate: decreased viable

Interactions	TRP3 All interactions details and references
	26 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-MS: 24 Two-hybrid: 2

Sequence Information

ChrXI:38154 to 36700 | |

Note: this feature is encoded on the Crick strand.

Genetic position: -153.8 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1455	38154..36700	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001694

TRP3 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TRP3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TRP3]

1)	Link, A. and Olson, M. (1989) Personal Communication, Mortimer Map Edition 10
2)	Paluh JL and Zalkin H (1983) Isolation of Saccharomyces cerevisiae TRP3. J Bacteriol 153(1):345-9
3)	Zalkin H, et al. (1984) Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase. J Biol Chem 259(6):3985-92
4)	Prantl F, et al. (1985) Purification and characterization of the indole-3-glycerolphosphate synthase/anthranilate synthase complex of Saccharomyces cerevisiae. Eur J Biochem 146(1):95-100
5)	Fantes PA, et al. (1976) Free tryptophan pool and tryptophan biosynthetic enzymes in Saccharomyces cerevisiae. Arch Microbiol 107(2):207-14

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.