Standard Name	TRP3 1
Systematic Name	YKL211C
Feature Type	ORF, Verified
Description	Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p (2, 3, 4, 5)
Name Description	TRyPtophan requiring

Chromosomal Location	ChrXI:38153 to 36699 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -153.8 cM

	View Computational GO annotations for TRP3
Molecular Function
Manually curated	contributes_to anthranilate synthase activity (IGI) indole-3-glycerol-phosphate synthase activity (IGI, IMP, ISS)
Biological Process
Manually curated	tryptophan biosynthetic process (IMP)
Cellular Component
Manually curated	anthranilate synthase complex (IPI)
High-throughput	cytoplasm (IDA)

Pathways	pathways of chorismate superpathway of phenylalanine, tyrosine and tryptophan biosynthesis tryptophan biosynthesis

Classical genetics
null	resistance to 5-fluoroanthranilic acid: increased resistance to 2-phenylethanol: decreased
unspecified	auxotrophy
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased heat sensitivity: increased oxidative stress resistance: decreased resistance to miconazole: decreased resistance to cycloheximide: decreased resistance to streptomycin: decreased resistance to ethanol: decreased resistance to CTBT: decreased resistance to arsenite(3-): decreased resistance to propolis extract: decreased resistance to methyl methanesulfonate: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to acrolein: decreased resistance to sorbate: decreased utilization of nitrogen source: absent viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	70 total interaction(s) for 58 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Reconstituted Complex: 7 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 30 Positive Genetic: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:38153 to 36699 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -153.8 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1455 38153..36699 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001694