Standard Name	TRP2 1
Systematic Name	YER090W
Feature Type	ORF, Verified
Description	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p (1, 2, 3, 4)
Name Description	TRyPtophan requiring

Chromosomal Location	ChrV:337949 to 339472 | ORF Map | GBrowse
	Genetic position: 76 cM

	View Computational GO annotations for TRP2
Molecular Function
Manually curated	anthranilate synthase activity (IDA, IGI, ISS)
Biological Process
Manually curated	tryptophan biosynthetic process (IMP)
Cellular Component
Manually curated	anthranilate synthase complex (IPI)
High-throughput	cytoplasm (IDA)

Pathways	pathways of chorismate superpathway of phenylalanine, tyrosine and tryptophan biosynthesis tryptophan biosynthesis

Classical genetics
null	resistance to 5-fluoroanthranilic acid: increased resistance to sulfathiazole: increased resistance to 6-hydroxylaminopurine: decreased resistance to 2-phenylethanol: decreased
unspecified	auxotrophy
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased oxidative stress resistance: decreased resistance to miconazole: decreased resistance to ethanol: decreased resistance to CTBT: decreased resistance to methyl methanesulfonate: decreased resistance to pentachlorophenol: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to sorbate: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal viable
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	106 total interaction(s) for 75 unique genes/features.
Physical Interactions	Affinity Capture-MS: 24 Affinity Capture-RNA: 2 Biochemical Activity: 1 PCA: 4 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 61 Positive Genetic: 8 Synthetic Growth Defect: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:337949 to 339472 | ORF Map | GBrowse
	This feature contains embedded feature(s): YER090C-A
	Genetic position: 76 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1524 337949..339472 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000892