TRP2/YER090W Summary

TRP2 BASIC INFORMATION

Standard Name	TRP2 1
Systematic Name	YER090W
Feature Type	ORF, Verified
Description	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p (1, 2, 3, 4)
Name Description	TRyPtophan requiring

GO Annotations	All TRP2 GO evidence and references
	View Computational GO annotations for TRP2
Molecular Function
Manually curated	anthranilate synthase activity (IDA, IGI, ISS)
Biological Process
Manually curated	tryptophan biosynthetic process (IMP)
Cellular Component
Manually curated	anthranilate synthase complex (IPI)
High-throughput	cytoplasm (IDA)

Pathways	pathways of chorismate superpathway of phenylalanine, tyrosine and tryptophan biosynthesis tryptophan biosynthesis

Mutant Phenotype	All TRP2 Phenotype details and references
Classical genetics
null	resistance to 6-hydroxylaminopurine: decreased resistance to 2-phenylethanol: decreased resistance to 5-fluoroanthranilic acid: increased
unspecified	auxotrophy
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased oxidative stress resistance: decreased resistance to miconazole: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to ethanol: decreased viable

Interactions	TRP2 All interactions details and references
	23 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 1 Biochemical Activity: 1 PCA: 3 Two-hybrid: 2

Sequence Information

ChrV:337945 to 339468 | |

This feature contains embedded feature(s): YER090C-A

Genetic position: 76 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1524	337945..339468	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000892

TRP2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TRP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TRP2]

1)	Zalkin H, et al. (1984) Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase. J Biol Chem 259(6):3985-92
2)	Prantl F, et al. (1985) Purification and characterization of the indole-3-glycerolphosphate synthase/anthranilate synthase complex of Saccharomyces cerevisiae. Eur J Biochem 146(1):95-100
3)	Graf R, et al. (1993) Analysis of feedback-resistant anthranilate synthases from Saccharomyces cerevisiae. J Bacteriol 175(4):1061-8
4)	Fantes PA, et al. (1976) Free tryptophan pool and tryptophan biosynthetic enzymes in Saccharomyces cerevisiae. Arch Microbiol 107(2):207-14

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