TRM7/YBR061C Summary Help

Standard Name TRM7 1
Systematic Name YBR061C
Feature Type ORF, Verified
Description 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively (1, 2)
Name Description Transfer RNA Methyltransferase 1
Gene Product Alias 2'-O-ribose tRNA anticodon loop methyltransferase 1
Chromosomal Location
ChrII:365719 to 364787 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TRM7 GO evidence and references
  View Computational GO annotations for TRM7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
57 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 10
  • Negative Genetic: 12
  • Positive Genetic: 16
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 310
Molecular Weight (Da) 34,700
Isoelectric Point (pI) 7.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:365719 to 364787 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..933 365719..364787 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000265
References cited on this page View Complete Literature Guide for TRM7
1) Pintard L, et al.  (2002) Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. EMBO J 21(7):1811-20
2) Guy MP, et al.  (2012) Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. RNA 18(10):1921-33