TRM44/YPL030W Summary Help

Standard Name TRM44 1
Systematic Name YPL030W
Feature Type ORF, Verified
Description tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene (1, 2)
Name Description TRna Methyltransferase 1
Chromosomal Location
ChrXVI:493543 to 495246 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TRM44 GO evidence and references
  View Computational GO annotations for TRM44
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Large-scale survey
null
overexpression
Resources
28 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Negative Genetic: 11
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 567
Molecular Weight (Da) 64,855
Isoelectric Point (pI) 8.77
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:493543 to 495246 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1704 493543..495246 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005951
References cited on this page View Complete Literature Guide for TRM44
1) Kotelawala L, et al.  (2008) Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. RNA 14(1):158-69
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91