TRA1/YHR099W Summary Help

Standard Name TRA1 1, 2
Systematic Name YHR099W
Feature Type ORF, Verified
Description Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation (1, 2, 3, 4)
Name Description similar to human TRRAP 1, 2
Chromosomal Location
ChrVIII:302761 to 313995 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TRA1 GO evidence and references
  View Computational GO annotations for TRA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 65 genes
Resources
Classical genetics
conditional
dominant negative
null
Large-scale survey
null
Resources
380 total interaction(s) for 192 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 156
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 59
  • Biochemical Activity: 2
  • Co-crystal Structure: 2
  • Co-fractionation: 2
  • Co-localization: 4
  • Co-purification: 6
  • FRET: 1
  • PCA: 7
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 116
  • Synthetic Lethality: 13
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 3,744
Molecular Weight (Da) 433,175
Isoelectric Point (pI) 6.51
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:302761 to 313995 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..11235 302761..313995 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001141
References cited on this page View Complete Literature Guide for TRA1
1) Grant PA, et al.  (1998) The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2(6):863-7
2) Saleh A, et al.  (1998) Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. J Biol Chem 273(41):26559-65
3) Brown CE, et al.  (2001) Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292(5525):2333-7
4) Bhaumik SR, et al.  (2004) In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev 18(3):333-43