Standard Name	TRA1 1, 2
Systematic Name	YHR099W
Feature Type	ORF, Verified
Description	Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation (1, 2, 3, 4)
Name Description	similar to human TRRAP 1, 2

Chromosomal Location	ChrVIII:302761 to 313995 | ORF Map | GBrowse

	View Computational GO annotations for TRA1
Molecular Function
Manually curated	contributes_to histone acetyltransferase activity (IDA)
Biological Process
Manually curated	DNA repair (IDA) histone acetylation (IDA, IPI) positive regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	histone acetyltransferase complex (IPI) NuA4 histone acetyltransferase complex (IPI) nucleus (IDA) SAGA complex (IDA) SLIK (SAGA-like) complex (IDA)
High-throughput	ASTRA complex (IDA)

Classical genetics
conditional	heat sensitivity: increased resistance to Calcofluor White and staurosporine: decreased resistance to Calcofluor White: decreased resistance to sirolimus: decreased
dominant negative	auxotrophy cold sensitivity: increased heat sensitivity: increased resistance to Calcofluor White: decreased resistance to tunicamycin: decreased resistance to tert-butyl hydroperoxide: decreased resistance to sirolimus: decreased resistance to geneticin: decreased resistance to chloramphenicol: decreased resistance to benomyl: decreased respiratory growth: decreased rate
null	inviable
Large-scale survey
null	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	371 total interaction(s) for 190 unique genes/features.
Physical Interactions	Affinity Capture-MS: 148 Affinity Capture-RNA: 1 Affinity Capture-Western: 59 Biochemical Activity: 2 Co-crystal Structure: 2 Co-fractionation: 2 Co-localization: 4 Co-purification: 6 FRET: 1 PCA: 7 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 116 Synthetic Lethality: 13 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:302761 to 313995 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..11235 302761..313995 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001141