TPP1/YMR156C Summary Help

Standard Name TPP1 1
Systematic Name YMR156C
Feature Type ORF, Verified
Description DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase (2, 3)
Name Description Three Prime Phosphatase 1
Chromosomal Location
ChrXIII:571016 to 570300 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TPP1 GO evidence and references
  View Computational GO annotations for TPP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
42 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 10
  • Positive Genetic: 3
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 8
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 238
Molecular Weight (Da) 27,383
Isoelectric Point (pI) 9.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:571016 to 570300 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..717 571016..570300 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004765
References cited on this page View Complete Literature Guide for TPP1
1) Vance JR and Wilson TE  (2001) Uncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1). J Biol Chem 276(18):15073-81
2) Vance JR and Wilson TE  (2001) Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases. Mol Cell Biol 21(21):7191-8
3) Deshpande RA and Wilson TE  (2004) Identification of DNA 3'-phosphatase active site residues and their differential role in DNA binding, Mg2+ coordination, and catalysis. Biochemistry 43(26):8579-89