Standard Name	TPM2 (see Nomenclature conflict Note)
Systematic Name	YIL138C
Feature Type	ORF, Verified
Description	Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication (1, 2, 3)
Name Description	TroPoMyosin
Gene Product Alias	tropomyosin

Chromosomal Location	ChrIX:89715 to 89230 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TPM2
Molecular Function
Manually curated	actin lateral binding (TAS)
Biological Process
Manually curated	actin filament bundle assembly (IGI) actin filament organization (TAS) actin polymerization or depolymerization (TAS) budding cell apical bud growth (TAS) budding cell isotropic bud growth (TAS) establishment of cell polarity (TAS) exocytosis (TAS) intracellular mRNA localization (TAS) mitochondrion inheritance (TAS) vacuole inheritance (TAS) vesicle-mediated transport (TAS)
Cellular Component
Manually curated	actin filament bundle (IDA) cellular bud neck contractile ring (IDA)

Classical genetics
overexpression	nuclear morphology: abnormal
Large-scale survey
null	competitive fitness: increased resistance to fluconazole: increased resistance to caffeine: increased resistance to camptothecin: increased resistance to bleomycin: increased resistance to hydroxyurea: increased resistance to tunicamycin: increased resistance to cycloheximide: decreased resistance to fenpropimorph: increased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	55 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 4 Co-crystal Structure: 1 PCA: 5 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 24 Phenotypic Enhancement: 10 Phenotypic Suppression: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:89715 to 89230 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..486 89715..89230 1994-12-10 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001400