TPD3/YAL016W Summary Help

Standard Name TPD3 1
Systematic Name YAL016W
Alias FUN32
Feature Type ORF, Verified
Description Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A (PP2A) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III (2, 3)
Name Description tRNA Processing Deficient 1
Chromosomal Location
ChrI:124879 to 126786 | ORF Map | GBrowse
Gbrowse
Genetic position: .5 cM
Gene Ontology Annotations All TPD3 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 75 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
129 total interaction(s) for 58 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 71
  • Affinity Capture-Western: 25
  • Co-fractionation: 2
  • PCA: 8
  • Reconstituted Complex: 1
  • Two-hybrid: 9

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Growth Defect: 3
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 4
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 635
Molecular Weight (Da) 70,906
Isoelectric Point (pI) 4.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:124879 to 126786 | ORF Map | GBrowse
SGD ORF map
Genetic position: .5 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1908 124879..126786 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000014
References cited on this page View Complete Literature Guide for TPD3
1) van Zyl WH, et al.  (1989) A general screen for mutant of Saccharomyces cerevisiae deficient in tRNA biosynthesis. Genetics 123(1):55-68
2) van Zyl W, et al.  (1992) Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae. Mol Cell Biol 12(11):4946-59
3) Wang Y and Burke DJ  (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol Cell Biol 17(2):620-6