Standard Name	TPD3
Systematic Name	YAL016W
Alias	FUN32
Feature Type	ORF, Verified
Description	Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III (1, 2)
Name Description	tRNA Processing Deficient 3

Chromosomal Location	ChrI:124879 to 126786 | ORF Map | GBrowse
	Genetic position: .5 cM

Molecular Function
Manually curated	contributes_to protein serine/threonine phosphatase activity (IDA, IMP)
Biological Process
Manually curated	mitotic spindle assembly checkpoint (IMP) regulation of translation (IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) cytoplasm (IDA) mating projection tip (IDA) nucleus (IDA) protein phosphatase type 2A complex (IDA) spindle pole body (IDA)

Classical genetics
null	acid pH resistance: decreased alkaline pH resistance: decreased apoptosis: decreased cell cycle progression in G1 phase: decreased duration cell cycle progression in S phase: decreased duration ionic stress resistance: decreased metal resistance: decreased alpha-factor secretion: decreased invertase secretion: decreased resistance to caffeine: decreased resistance to sirolimus: decreased resistance to nocodazole: decreased
Large-scale survey
null	acid pH resistance: decreased alkaline pH resistance: decreased cell size: increased glycogen accumulation: decreased proton accumulation: decreased competitive fitness: decreased dessication resistance: decreased haploproficient hyperosmotic stress resistance: decreased lipid particle morphology: abnormal metal resistance: decreased oxidative stress resistance: decreased resistance to ethanol: decreased resistance to methanol: decreased resistance to hygromycin B: decreased resistance to hydroxyurea: decreased resistance to miconazole: decreased resistance to citric acid: decreased resistance to acetic acid: decreased resistance to hydrogen chloride: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to boric acid: decreased resistance to sorbate: decreased resistance to L-1,4-dithiothreitol: decreased respiratory growth: absent telomere length: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	126 total interaction(s) for 58 unique genes/features.
Physical Interactions	Affinity Capture-MS: 69 Affinity Capture-Western: 24 Co-fractionation: 2 PCA: 8 Reconstituted Complex: 1 Two-hybrid: 9
Genetic Interactions	Negative Genetic: 1 Synthetic Growth Defect: 3 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 4 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:124879 to 126786 | ORF Map | GBrowse
	Genetic position: .5 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1908 124879..126786 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000014