TOF2/YKR010C Summary Help

TOF2 BASIC INFORMATION

Standard Name TOF2 1
Systematic Name YKR010C
Feature Type ORF, Verified
Description Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site (2, 3, 4, 5)
Name Description TOpoisomerase I-interacting Factor 1
GO Annotations All TOF2 GO evidence and references
    View Computational GO annotations for TOF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All TOF2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions TOF2 All interactions details and references
56 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 9
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2
Sequence Information
ChrXI:460882 to 458567 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2316 460882..458567 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001718

TOF2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for TOF2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TOF2]

1) Park H and Sternglanz R  (1999) Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae. Yeast 15(1):35-41
2) Huang J, et al.  (2006) Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev 20(20):2887-901
3) Geil C, et al.  (2008) A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis. Curr Biol 18(13):1001-5
4) Waples WG, et al.  (2009) Putting the Brake on FEAR: Tof2 Promotes the Biphasic Release of Cdc14 Phosphatase during Mitotic Exit. Mol Biol Cell 20(1):245-55
5) Johzuka K and Horiuchi T  (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35