TMA22/YJR014W Summary Help

Standard Name TMA22 1
Systematic Name YJR014W
Feature Type ORF, Verified
Description Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Translation Machinery Associated 1
Chromosomal Location
ChrX:461829 to 462425 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TMA22 GO evidence and references
  View Computational GO annotations for TMA22
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Large-scale survey
null
Resources
72 total interaction(s) for 61 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 2
  • Biochemical Activity: 3
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 34
  • Positive Genetic: 7
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 198
Molecular Weight (Da) 22,495
Isoelectric Point (pI) 8.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:461829 to 462425 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..597 461829..462425 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Retired NameRBF22
Primary SGDIDS000003775
References cited on this page View Complete Literature Guide for TMA22
1) Fleischer TC, et al.  (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
2) Tu J, et al.  (2000) Molecular characterization of a granulocyte macrophage-colony-stimulating factor receptor alpha subunit-associated protein, GRAP. Blood 96(3):794-9
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76