Standard Name	TLG2 1
Systematic Name	YOL018C
Feature Type	ORF, Verified
Description	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) (2, 3, 4, 5)
Name Description	T-snare affecting a Late Golgi compartment 1

Chromosomal Location	ChrXV:292074 to 290881 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TLG2
Molecular Function
Manually curated	SNAP receptor activity (IDA)
Biological Process
Manually curated	CVT pathway (IMP) endocytosis (IMP) Golgi to vacuole transport (IGI) inositolphosphoceramide metabolic process (IGI, IMP) mannosyl-inositol phosphorylceramide metabolic process (IGI, IMP) protein exit from endoplasmic reticulum (IGI) vesicle fusion (IDA)
Cellular Component
Manually curated	integral to endosome membrane (IDA) SNARE complex (IPI) trans-Golgi network (IDA)

Classical genetics
null	inositol phosphoceramide accumulation: decreased mannosylinositol phosphorylceramide accumulation: decreased chronological lifespan: increased endocytosis: decreased killer toxin resistance: decreased metal resistance: decreased Acb1p secretion: absent carboxypeptidase Y (Prc1p) modification: decreased resistance to caffeine: decreased resistance to Echinocandin B: decreased resistance to Papulacandin B: decreased resistance to gentamycin: decreased resistance to brefeldin A: decreased resistance to monensin: decreased resistance to calcium dichloride: decreased toxin resistance: decreased viable
Large-scale survey
null	auxotrophy rubidium(1+) accumulation: increased competitive fitness: decreased haploinsufficient ionic stress resistance: decreased metal resistance: decreased resistance to hygromycin B: decreased resistance to curcumin: decreased resistance to wortmannin: normal resistance to ciclopirox olamine: decreased resistance to mefloquine: decreased resistance to dimethyl sulfoxide: decreased resistance to sirolimus: decreased resistance to mycophenolic acid: decreased resistance to hydroxyurea: decreased resistance to fluconazole: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to bleomycin: decreased resistance to spermine: decreased resistance to hydrogen chloride: decreased resistance to (S)-lactic acid: decreased resistance to wortmannin: decreased resistance to monensin: decreased resistance to methyl methanesulfonate: increased resistance to fenpropimorph: increased resistance to camptothecin: increased resistance to nickel sulfate: increased resistance to amitrole: decreased resistance to streptomycin: decreased resistance to lithium chloride: decreased resistance to strontium dichloride: decreased resistance to rubidium chloride: decreased resistance to ruthenium red: decreased resistance to latrunculin B: decreased resistance to diltiazem-HCl: decreased resistance to cesium chloride: decreased resistance to chlorpromazine: decreased resistance to nordihydroguaiaretic acid: decreased resistance to 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to ethylenediaminetetraacetic acid: decreased stress resistance: decreased toxin resistance: decreased vegetative growth: abnormal viable
overexpression	resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	746 total interaction(s) for 349 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 23 Biochemical Activity: 2 Co-purification: 35 PCA: 2 Reconstituted Complex: 4 Two-hybrid: 9
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 483 Phenotypic Enhancement: 85 Phenotypic Suppression: 12 Positive Genetic: 46 Synthetic Growth Defect: 30 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:292074 to 290881 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1194 292074..290881 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005378