TIF11/YMR260C Summary Help

Standard Name TIF11 1
Systematic Name YMR260C
Feature Type ORF, Verified
Description Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 (1, 2, 3)
Name Description Translation Initiation Factor 1
Chromosomal Location
ChrXIII:789839 to 789378 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TIF11 GO evidence and references
  View Computational GO annotations for TIF11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
48 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 6
  • Affinity Capture-Western: 8
  • Biochemical Activity: 1
  • Co-crystal Structure: 2
  • PCA: 3
  • Reconstituted Complex: 6
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 4
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 4
  • Synthetic Lethality: 5
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 153
Molecular Weight (Da) 17,435
Isoelectric Point (pI) 4.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:789839 to 789378 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..462 789839..789378 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004873
References cited on this page View Complete Literature Guide for TIF11
1) Wei CL, et al.  (1995) Characterization of yeast translation initiation factor 1A and cloning of its essential gene. J Biol Chem 270(39):22788-94
2) Olsen DS, et al.  (2003) Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. EMBO J 22(2):193-204
3) Maag D, et al.  (2005) A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon. Mol Cell 17(2):265-75