THR4/YCR053W Summary Help

Standard Name THR4 1
Systematic Name YCR053W
Feature Type ORF, Verified
Description Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway (2, 3)
Name Description THReonine requiring
Chromosomal Location
ChrIII:216697 to 218241 | ORF Map | GBrowse
Gbrowse
Genetic position: 51 cM
Gene Ontology Annotations All THR4 GO evidence and references
  View Computational GO annotations for THR4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 8 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
Resources
449 total interaction(s) for 337 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 3
  • Protein-peptide: 1

Genetic Interactions
  • Negative Genetic: 371
  • Positive Genetic: 45
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 10
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 514
Molecular Weight (Da) 57,474
Isoelectric Point (pI) 5.39
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:216697 to 218241 | ORF Map | GBrowse
SGD ORF map
Genetic position: 51 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1545 216697..218241 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000649
References cited on this page View Complete Literature Guide for THR4
1) Mortimer RK and Hawthorne DC  (1966) Genetic mapping in Saccharomyces. Genetics 53(1):165-73
2) Ramos C and Calderon IL  (1994) Biochemical evidence that the Saccharomyces cerevisiae THR4 gene encodes threonine synthetase. FEBS Lett 351(3):357-9
3) Mannhaupt G, et al.  (1990) Analysis of the THR4 region on chromosome III of the yeast Saccharomyces cerevisiae. Yeast 6(4):353-61