THR4/YCR053W Summary

THR4 BASIC INFORMATION

Standard Name	THR4 1
Systematic Name	YCR053W
Feature Type	ORF, Verified
Description	Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway (2, 3)
Name Description	THReonine requiring

GO Annotations	All THR4 GO evidence and references
	View Computational GO annotations for THR4
Molecular Function
Manually curated	threonine synthase activity (IMP)
Biological Process
Manually curated	endocytosis (IMP) threonine metabolic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	superpathway of threonine and methionine biosynthesis superpathway of threonine biosynthesis threonine biosynthesis

Mutant Phenotype	All THR4 Phenotype details and references
Classical genetics
unspecified	auxotrophy
Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased petite-negative resistance to citric acid: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to doxorubicin: decreased resistance to hydroxyurea: decreased respiratory growth: decreased rate sporulation: decreased toxin resistance: decreased viable

Interactions	THR4 All interactions details and references
	18 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Lethality: 8

Sequence Information

ChrIII:216693 to 218237 | |

Genetic position: 51 cM

Last Update

Coordinates: 2006-01-12 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1545	216693..218237	2006-01-12	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000649

THR4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for THR4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for THR4]

1)	Mortimer RK and Hawthorne DC (1966) Genetic mapping in Saccharomyces. Genetics 53(1):165-73
2)	Ramos C and Calderon IL (1994) Biochemical evidence that the Saccharomyces cerevisiae THR4 gene encodes threonine synthetase. FEBS Lett 351(3):357-9
3)	Mannhaupt G, et al. (1990) Analysis of the THR4 region on chromosome III of the yeast Saccharomyces cerevisiae. Yeast 6(4):353-61

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