THR1/YHR025W Summary

THR1 BASIC INFORMATION

Standard Name	THR1 1
Systematic Name	YHR025W
Feature Type	ORF, Verified
Description	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway (2, 3)
Name Description	THReonine requiring

GO Annotations	All THR1 GO evidence and references
	View Computational GO annotations for THR1
Molecular Function
Manually curated	homoserine kinase activity (IDA, ISS)
Biological Process
Manually curated	homoserine metabolic process (IDA) isoleucine metabolic process (TAS) methionine metabolic process (TAS) threonine metabolic process (TAS)
Cellular Component
Manually curated	cellular_component unknown (ND)

Pathways	superpathway of threonine and methionine biosynthesis superpathway of threonine biosynthesis threonine biosynthesis

Mutant Phenotype	All THR1 Phenotype details and references
Classical genetics
null	resistance to mycophenolic acid: decreased resistance to hydroxyurea: decreased
Large-scale survey
null	acid pH resistance: decreased polyphosphate accumulation: abnormal competitive fitness: decreased petite-negative resistance to citric acid: decreased resistance to mycophenolic acid: decreased resistance to doxorubicin: decreased resistance to hydroxyurea: decreased resistance to acetaldehyde: decreased respiratory growth: decreased rate toxin resistance: decreased viable

Interactions	THR1 All interactions details and references
	67 total interaction(s) for 63 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 PCA: 1 Two-hybrid: 5
Genetic Interactions	Phenotypic Enhancement: 26 Phenotypic Suppression: 20 Synthetic Growth Defect: 3 Synthetic Lethality: 7

Sequence Information

ChrVIII:159431 to 160504 | |

Genetic position: 26 cM

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1074	159431..160504	2005-11-07	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001067

THR1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for THR1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for THR1]

1)	Mortimer RK and Hawthorne DC (1966) Genetic mapping in Saccharomyces. Genetics 53(1):165-73
2)	Mannhaupt G, et al. (1990) Yeast homoserine kinase. Characteristics of the corresponding gene, THR1, and the purified enzyme, and evolutionary relationships with other enzymes of threonine metabolism. Eur J Biochem 191(1):115-22
3)	Schultes NP, et al. (1990) Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Gene 96(2):177-80

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.