THI73/YLR004C Summary Help

Standard Name THI73 1
Systematic Name YLR004C
Feature Type ORF, Verified
Description Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs (1, 2, 3, 4, 5)
Name Description THI regulon 1
Chromosomal Location
ChrXII:159505 to 157934 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All THI73 GO evidence and references
  View Computational GO annotations for THI73
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Large-scale survey
null
overexpression
Resources
33 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • PCA: 7

Genetic Interactions
  • Negative Genetic: 19
  • Positive Genetic: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 523
Molecular Weight (Da) 58,531
Isoelectric Point (pI) 8.26
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:159505 to 157934 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1572 159505..157934 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003994
References cited on this page View Complete Literature Guide for THI73
1) Mojzita D and Hohmann S  (2006) Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 276(2):147-61
2) Llorente B and Dujon B  (2000) Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w). FEBS Lett 475(3):237-41
3) Paulsen IT, et al.  (1998) Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. FEBS Lett 430(1-2):116-25
4) Epstein CB, et al.  (2001) Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell 12(2):297-308
5) Palkova Z, et al.  (2002) Ammonia pulses and metabolic oscillations guide yeast colony development. Mol Biol Cell 13(11):3901-14