THI7/YLR237W Summary Help

Standard Name THI7 1
Systematic Name YLR237W
Alias THI10 2
Feature Type ORF, Verified
Description Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia (1, 2, 3, 4)
Name Description THIamine metabolism
Chromosomal Location
ChrXII:612367 to 614163 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All THI7 GO evidence and references
  View Computational GO annotations for THI7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
Resources
48 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • PCA: 5

Genetic Interactions
  • Negative Genetic: 30
  • Phenotypic Enhancement: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 598
Molecular Weight (Da) 66,903
Isoelectric Point (pI) 7.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:612367 to 614163 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1797 612367..614163 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000004227
References cited on this page View Complete Literature Guide for THI7
1) Singleton CK  (1997) Identification and characterization of the thiamine transporter gene of Saccharomyces cerevisiae. Gene 199(1-2):111-21
2) Enjo F, et al.  (1997) Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. J Biol Chem 272(31):19165-70
3) Stagg AR, et al.  (1999) Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. J Clin Invest 103(5):723-9
4) Ceschin J, et al.  (2014) Identification of Yeast and Human 5-Aminoimidazole-4-carboxamide-1-?-d-ribofuranoside (AICAr) Transporters. J Biol Chem 289(24):16844-16854