TFC6/YDR362C Summary Help

Standard Name TFC6 1
Systematic Name YDR362C
Feature Type ORF, Verified
Description Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 (1, 2)
Name Description Transcription Factor C 1
Gene Product Alias tau 91 3
Chromosomal Location
ChrIV:1198697 to 1196679 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TFC6 GO evidence and references
  View Computational GO annotations for TFC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 22 genes
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
reduction of function
Resources
40 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-Western: 10
  • Biochemical Activity: 2
  • Co-fractionation: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 672
Molecular Weight (Da) 74,708
Isoelectric Point (pI) 6.57
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1198697 to 1196679 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2019 1198697..1196679 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002770
References cited on this page View Complete Literature Guide for TFC6
1) Arrebola R, et al.  (1998) Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding. Mol Cell Biol 18(1):1-9
2) Geiduschek EP and Kassavetis GA  (2001) The RNA polymerase III transcription apparatus. J Mol Biol 310(1):1-26
3) Jourdain S, et al.  (2003) The tau95 subunit of yeast TFIIIC influences upstream and downstream functions of TFIIIC.DNA complexes. J Biol Chem 278(12):10450-7