TFB4/YPR056W Summary Help

Standard Name TFB4 1
Systematic Name YPR056W
Feature Type ORF, Verified
Description Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p (1, 2, 3)
Name Description Transcription Factor B subunit 4 1
Chromosomal Location
ChrXVI:671126 to 672142 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TFB4 GO evidence and references
  View Computational GO annotations for TFB4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
null
reduction of function
Large-scale survey
null
reduction of function
Resources
77 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 15
  • Co-crystal Structure: 1
  • Co-purification: 19
  • PCA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 338
Molecular Weight (Da) 37,457
Isoelectric Point (pI) 9.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:671126 to 672142 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1017 671126..672142 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006260
References cited on this page View Complete Literature Guide for TFB4
1) Feaver WJ, et al.  (1997) Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits. J Biol Chem 272(31):19319-27
2) Feaver WJ, et al.  (2000) Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair. J Biol Chem 275(8):5941-6
3) Lee TI and Young RA  (2000) Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34:77-137