Standard Name	TFA1 1
Systematic Name	YKL028W
Feature Type	ORF, Verified
Description	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening (1, 2, 3)
Name Description	Transcription Factor a, subunit 1 1

Chromosomal Location	ChrXI:385758 to 387206 | ORF Map | GBrowse

	View Computational GO annotations for TFA1
Molecular Function
Manually curated	contributes_to RNA polymerase II core binding (IDA) RNA polymerase II core binding (IPI) contributes_to single-stranded DNA binding (IDA) contributes_to TFIIH-class transcription factor binding (IDA)
Biological Process
Manually curated	transcription from RNA polymerase II promoter (IDA, IMP) transcriptional open complex formation at RNA polymerase II promoter (IDA, IGI)
Cellular Component
Manually curated	transcription factor TFIIE complex (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	cold sensitivity: increased heat sensitivity: increased
null	inviable
Large-scale survey
null	inviable
reduction of function	colony sectoring: increased competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	76 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 3 Affinity Capture-Western: 5 Co-purification: 12 PCA: 3 Reconstituted Complex: 9 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 1 Positive Genetic: 2 Synthetic Growth Defect: 3 Synthetic Lethality: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:385758 to 387206 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1449 385758..387206 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001511