TEP1/YNL128W Summary Help

Standard Name TEP1 1
Systematic Name YNL128W
Feature Type ORF, Verified
Description PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 (1, 2, 3, 4)
Name Description TEnsin-like Phosphatase 1
Chromosomal Location
ChrXIV:382359 to 383663 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TEP1 GO evidence and references
  View Computational GO annotations for TEP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
50 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 36
  • Positive Genetic: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 434
Molecular Weight (Da) 50,152
Isoelectric Point (pI) 6.78
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:382359 to 383663 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1305 382359..383663 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005072
References cited on this page View Complete Literature Guide for TEP1
1) Heymont J, et al.  (2000) TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Proc Natl Acad Sci U S A 97(23):12672-7
2) Mitra P, et al.  (2004) A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol 166(2):205-11
3) Rodriguez-Escudero I, et al.  (2005) Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Biochem J 390(Pt 2):613-23
4) Maehama T, et al.  (2001) PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem 70():247-79