TEM1/YML064C Summary Help

Standard Name TEM1 1
Systematic Name YML064C
Feature Type ORF, Verified
Description GTP-binding protein of the Ras superfamily; involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis (1, 2, 3)
Name Description TErmination of M phase 1
Chromosomal Location
ChrXIII:145876 to 145139 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TEM1 GO evidence and references
  View Computational GO annotations for TEM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
conditional
null
Large-scale survey
conditional
null
reduction of function
Resources
211 total interaction(s) for 124 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 44
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 28
  • Biochemical Activity: 5
  • Co-localization: 3
  • PCA: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 50

Genetic Interactions
  • Dosage Lethality: 6
  • Dosage Rescue: 27
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 10
  • Synthetic Rescue: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 245
Molecular Weight (Da) 27,296
Isoelectric Point (pI) 10.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:145876 to 145139 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..738 145876..145139 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004529
References cited on this page View Complete Literature Guide for TEM1
1) Shirayama M, et al.  (1994) The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase. Mol Cell Biol 14(11):7476-82
2) Shou W, et al.  (1999) Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97(2):233-44
3) Lippincott J, et al.  (2001) The Tem1 small GTPase controls actomyosin and septin dynamics during cytokinesis. J Cell Sci 114(Pt 7):1379-86