TEL2/YGR099W Summary Help

Standard Name TEL2 1
Systematic Name YGR099W
Feature Type ORF, Verified
Description Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 (1, 2, 3, 4, 5)
Name Description TELomere maintenance
Chromosomal Location
ChrVII:687899 to 689965 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TEL2 GO evidence and references
  View Computational GO annotations for TEL2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
conditional
null
reduction of function
Large-scale survey
conditional
null
reduction of function
Resources
426 total interaction(s) for 405 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 231
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 156
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 688
Molecular Weight (Da) 78,686
Isoelectric Point (pI) 6.64
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:687899 to 689965 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2067 687899..689965 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003331
References cited on this page View Complete Literature Guide for TEL2
1) Runge KW and Zakian VA  (1996) TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 16(6):3094-105
2) Kota RS and Runge KW  (1998) The yeast telomere length regulator TEL2 encodes a protein that binds to telomeric DNA. Nucleic Acids Res 26(6):1528-35
3) Kota RS and Runge KW  (1999) Tel2p, a regulator of yeast telomeric length in vivo, binds to single-stranded telomeric DNA in vitro. Chromosoma 108(5):278-90
4) Shevchenko A, et al.  (2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol 9(11):R167
5) Stirling PC, et al.  (2011) The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components. PLoS Genet 7(4):e1002057