Standard Name	TEL2 1
Systematic Name	YGR099W
Feature Type	ORF, Verified
Description	Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 (1, 2, 3, 4, 5)
Name Description	TELomere maintenance

Chromosomal Location	ChrVII:687899 to 689965 | ORF Map | GBrowse

	View Computational GO annotations for TEL2
Molecular Function
Manually curated	telomeric DNA binding (IDA)
Biological Process
Manually curated	protein localization to chromosome (IMP) telomere maintenance (IMP) telomere maintenance via telomerase (IMP)
Cellular Component
Manually curated	nuclear telomere cap complex (IDA)
High-throughput	ASTRA complex (IDA)

Classical genetics
conditional	cell cycle progression in G1 phase: arrested heat sensitivity: increased FLAG-Mec1p accumulation: decreased Tel1p accumulation: decreased Tor1p accumulation: decreased Gat1p-GFP distribution: abnormal Tel1p distribution: abnormal Mrc1p modification: delayed Rad53p modification: delayed Xrs2p modification: delayed Rad9p modification: delayed resistance to sirolimus: decreased silencing: decreased telomere length: abnormal telomere length: decreased
null	chromosome/plasmid maintenance: decreased inviable
reduction of function	resistance to sirolimus: decreased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	inviable
reduction of function	competitive fitness: increased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	424 total interaction(s) for 404 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 231 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 156 Synthetic Growth Defect: 2 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:687899 to 689965 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2067 687899..689965 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003331