TEL1/YBL088C Summary Help

TEL1 BASIC INFORMATION

Standard Name TEL1 1
Systematic Name YBL088C
Feature Type ORF, Verified
Description Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene (2, 3, 4, 5 and see Summary Paragraph)
Name Description TELomere maintenance
GO Annotations All TEL1 GO evidence and references
    View Computational GO annotations for TEL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All TEL1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions TEL1 All interactions details and references
110 total interaction(s) for 64 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 7
  • Biochemical Activity: 6
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 4
  • Phenotypic Enhancement: 59
  • Phenotypic Suppression: 11
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 3
  • Synthetic Rescue: 8
Sequence Information
ChrII:59379 to 51016 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -60 cM
Last Update Coordinates: 2004-01-29 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..8364 59379..51016 2004-01-29 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000184

TEL1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for TEL1

SUMMARY PARAGRAPH for TEL1

TEL1 was originally identified in a mutant screen to find genes involved in maintaining telomere length (6). It was later shown that Tel1p is a phosphatidylinositol 3-kinase homolog and is related to the human ATM (ataxia telangiectasia mutated) gene (7, 8). However, despite its similarity to phosphatidylinositol 3-kinases, Tel1p has been shown to have protein kinase activity (9). Ataxia-telangiectasia (AT) is an autosomal recessive disorder that causes cerebellar ataxia, telangiectases, immune defects, and a predisposition to cancer; AT cells are hypersensitive to killing by ionizing radiation (OMIM:607585). Tel1p is a member of the PIK-related kinase family that includes Mec1p, Tor1p, and Tor2p and is involved in DNA repair, recombination, and regulation of the cell cycle (10, 11).

Last updated: 2005-05-27

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TEL1]

1) Kronmal, S. and Petes, T.  (1992) Personal Communication, Mortimer Map Edition 11
2) Ritchie KB and Petes TD  (2000) The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155(1):475-9
3) Craven RJ, et al.  (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161(2):493-507
4) Giannattasio M, et al.  (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002
5) Nakada D, et al.  (2003) The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res 31(6):1715-24
6) Lustig AJ and Petes TD  (1986) Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A 83(5):1398-402
7) Greenwell PW, et al.  (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82(5):823-9
8) Morrow DM, et al.  (1995) TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82(5):831-40
9) Mallory JC and Petes TD  (2000) Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proc Natl Acad Sci U S A 97(25):13749-54
10) Keith CT and Schreiber SL  (1995) PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270(5233):50-1
11) Jackson SP  (1996) The recognition of DNA damage. Curr Opin Genet Dev 6(1):19-25