TEL04R Summary Help

Systematic Name TEL04R
Feature Type telomere
Description Telomeric region on the right arm of Chromosome IV; composed of an X element core sequence, X element combinatorial repeats, a short stretch of telomeric repeats, and a long Y' element (1, 2 and see Summary Paragraph)
Chromosomal Location
ChrIV:1524625 to 1531933 | ORF Map | GBrowse
Gbrowse
Genetic position: 321 cM
sequence information
ChrIV:1524625 to 1531933 | ORF Map | GBrowse
This feature contains embedded feature(s): YDR543C | YDR544C | YRF1-1 | YDR545C-A | TEL04R-TR | TEL04R-XC | TEL04R-XR | TEL04R-YP
SGD ORF map
Genetic position: 321 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-09
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Resources
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Primary SGDIDS000028948
SUMMARY PARAGRAPH for TEL04R

The chromosome ends of Saccharomyces cerevisiae are complex mosaics of several different types of telomeric and subtelomeric elements known as X element core sequences, X element combinatorial repeats, telomeric repeats, and Y' elements (2). The X element core sequence, a small conserved element of ~475 bp containing an ARS sequence and in most cases an Abf1p binding site, is the only region shared by all chromosome ends (2, 1). The X element combinatorial repeats, formerly known as subtelomeric repeats or STRs, are located between the X element core sequence and the telomeric end and are usually present as a combination of one or more of several types of smaller elements designated D, C, B, or A (2, 1). The telomeric repeat is a G-rich terminal sequence of the form (TG1-3)n that is maintained by telomerase (1). The Y' element is a helicase-encoding repetitive sequence found in many but not all subtelomeric regions next to the telomeric repeats, or adjacent X element combinatorial repeats, either as a single copy or tandem repeat of two to four copies (3, 1, 4). Possible functions of telomeric regions include roles in chromosomal segregation, maintenance of chromosome stability, recombinational sequestering, or as a barrier to transcriptional silencing (2, 1).

TEL04R, the right telomeric region of chromosome IV, is composed of an X element core sequence TEL04R-XC containing an ARS consensus sequence, an Abf1p binding site and a dubious ORF YDR543C, X element combinatorial repeats TEL04R-XR of the D, C, B and A types containing Tbf1p binding sites and spanning dubious ORF YDR544C, a short stretch of telomeric repeats TEL04R-TR also spanning dubious ORF YDR544C, and a long Y' (Y'-L) element TEL04R-YP containing an ARS consensus sequence, a region of 36-bp repeats, a verified ORF YRF1-1/YDR545W and a dubious ORF YDR545C-A.

Click on the following figure for more details:

telomere map

Further information can be found at the website of Dr. Ed Louis, Institute of Genetics, The University of Nottingham.

Last updated: 2003-10-29 Contact SGD

References cited on this page View Complete Literature Guide for TEL04R
1) Louis EJ  (1995) The chromosome ends of Saccharomyces cerevisiae. Yeast 11(16):1553-73
2) Louis EJ, et al.  (1994) The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics 136(3):789-802
3) Louis EJ and Haber JE  (1992) The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics 131(3):559-74
4) Yamada M, et al.  (1998) Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. J Biol Chem 273(50):33360-6