TEL02L Summary Help

Systematic Name TEL02L
Feature Type telomere
Description Telomeric region on the left arm of Chromosome II; annotated components include an X element core sequence, X element combinatorial repeats, and a short Y' element; TEL02L does have telomeric repeats (TEL02L-TR), but they are missing from the genome annotation due to difficulties encountered during sequencing and/or assembly (1, 2 and see Summary Paragraph)
Chromosomal Location
ChrII:6608 to 1 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -80 cM
sequence information
ChrII:6608 to 1 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YBL109W | YBL111C | YBL112C | YBL113C | YBL113W-A | TEL02L-XC | TEL02L-XR | TEL02L-YP
Genetic position: -80 cM
Last Update Coordinates: 2003-09-09 | Sequence: 2003-09-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
External Links All Associated Seq | Search all NCBI (Entrez)
Primary SGDIDS000028867

The chromosome ends of Saccharomyces cerevisiae are complex mosaics of several different types of telomeric and subtelomeric elements known as X element core sequences, X element combinatorial repeats, telomeric repeats, and Y' elements (2). The X element core sequence, a small conserved element of ~475 bp containing an ARS sequence and in most cases an Abf1p binding site, is the only region shared by all chromosome ends (2, 1). The X element combinatorial repeats, formerly known as subtelomeric repeats or STRs, are located between the X element core sequence and the telomeric end and are usually present as a combination of one or more of several types of smaller elements designated D, C, B, or A (2, 1). The telomeric repeat is a G-rich terminal sequence of the form (TG1-3)n that is maintained by telomerase (1). The Y' element is a helicase-encoding repetitive sequence found in many but not all subtelomeric regions next to the telomeric repeats, or adjacent X element combinatorial repeats, either as a single copy or tandem repeat of two to four copies (3, 1, 4). Possible functions of telomeric regions include roles in chromosomal segregation, maintenance of chromosome stability, recombinational sequestering, or as a barrier to transcriptional silencing (2, 1).

TEL02L, the left telomeric region of chromosome II, is composed of an X element core sequence TEL02L-XC containing an ARS consensus sequence and an Abf1p binding site, X element combinatorial repeats TEL02L-XR of the D, C, B and A types containing Tbf1p binding sites and a dubious ORF YBL109W, and a short Y' (Y'-S) element TEL02L-YP containing an ARS consensus sequence, a region of 36-bp repeats, three uncharacterized ORFs (YBL111C, YBL112C, and YBL113C) and one dubious ORF YBL113W-A.

Click on the following figure for more details:

telomere map

Further information can be found at the website of Dr. Ed Louis, Institute of Genetics, The University of Nottingham.

Last updated: 2003-10-29 Contact SGD

References cited on this page View Complete Literature Guide for TEL02L
1) Louis EJ  (1995) The chromosome ends of Saccharomyces cerevisiae. Yeast 11(16):1553-73
2) Louis EJ, et al.  (1994) The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics 136(3):789-802
3) Louis EJ and Haber JE  (1992) The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics 131(3):559-74
4) Yamada M, et al.  (1998) Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. J Biol Chem 273(50):33360-6