Standard Name	TEF4
Systematic Name	YKL081W
Alias	EFC1
Feature Type	ORF, Verified
Description	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex (1, 2)
Name Description	Translation Elongation Factor 1

Chromosomal Location	ChrXI:282891 to 284455 | ORF Map | GBrowse

	View Computational GO annotations for TEF4
Molecular Function
Manually curated	translation elongation factor activity (TAS)
Biological Process
Manually curated	translational elongation (TAS)
Cellular Component
Manually curated	eukaryotic translation elongation factor 1 complex (ISS) ribosome (TAS)
High-throughput	mitochondrion (IDA)

Classical genetics
null	metal resistance: decreased resistance to tellurite: increased
Large-scale survey
null	acid pH resistance: decreased alkaline pH resistance: decreased polyphosphate accumulation: abnormal competitive fitness: decreased endocytosis: decreased haploinsufficient metal resistance: decreased resistance to camptothecin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to cycloheximide: decreased resistance to neomycin: decreased resistance to tunicamycin: increased resistance to sirolimus: decreased resistance to propolis extract: decreased resistance to quinine: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to wortmannin: normal resistance to methyl methanesulfonate: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	215 total interaction(s) for 181 unique genes/features.
Physical Interactions	Affinity Capture-MS: 75 Affinity Capture-RNA: 6 Affinity Capture-Western: 2 Biochemical Activity: 1 PCA: 2 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 99 Phenotypic Enhancement: 5 Phenotypic Suppression: 1 Positive Genetic: 10 Synthetic Growth Defect: 6 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:282891 to 284455 | ORF Map | GBrowse
	This feature contains embedded feature(s): SNR38
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..205 282891..283095 2011-02-03 1996-07-31 Intron 206..531 283096..283421 2011-02-03 1996-07-31 CDS 532..1565 283422..284455 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (206 - 531)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001564