TEF4/YKL081W Summary Help

Standard Name TEF4 1
Systematic Name YKL081W
Alias EFC1
Feature Type ORF, Verified
Description Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex (1, 2)
Name Description Translation Elongation Factor 1
Chromosomal Location
ChrXI:282891 to 284455 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TEF4 GO evidence and references
  View Computational GO annotations for TEF4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
223 total interaction(s) for 185 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 80
  • Affinity Capture-RNA: 8
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • PCA: 2
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 99
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 10
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 412
Molecular Weight (Da) 46,520
Isoelectric Point (pI) 8.09
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:282891 to 284455 | ORF Map | GBrowse
This feature contains embedded feature(s): SNR38
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..205 282891..283095 2011-02-03 1996-07-31
Intron 206..531 283096..283421 2011-02-03 1996-07-31
CDS 532..1565 283422..284455 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001564
References cited on this page View Complete Literature Guide for TEF4
1) Kinzy TG, et al.  (1994) Multiple genes encode the translation elongation factor EF-1 gamma in Saccharomyces cerevisiae. Nucleic Acids Res 22(13):2703-7
2) Jeppesen MG, et al.  (2003) The crystal structure of the glutathione S-transferase-like domain of elongation factor 1Bgamma from Saccharomyces cerevisiae. J Biol Chem 278(47):47190-8