TEF2/YBR118W Summary

TEF2 BASIC INFORMATION

Standard Name	TEF2
Systematic Name	YBR118W
Feature Type	ORF, Verified
Description	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus (1, 2) Also known as: EF-1 alpha
Name Description	Translation Elongation Factor 1

GO Annotations	All TEF2 GO evidence and references
	View Computational GO annotations for TEF2
Molecular Function
Manually curated	GDP binding (IDA) GTP binding (IDA) translation elongation factor activity (IMP)
Biological Process
Manually curated	translational elongation (IMP) tRNA export from nucleus (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) eukaryotic translation elongation factor 1 complex (ISS) ribosome (TAS)

Mutant Phenotype	All TEF2 Phenotype details and references
Large-scale survey
null	viable

Interactions	TEF2 All interactions details and references
	97 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-Western: 3 Biochemical Activity: 11 Co-crystal Structure: 2 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 3 Phenotypic Enhancement: 18 Phenotypic Suppression: 20 Synthetic Growth Defect: 5 Synthetic Lethality: 3

Sequence Information

ChrII:477665 to 479041 | |

Genetic position: 61 cM

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1377	477665..479041	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000322

TEF2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TEF2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TEF2]

1)	Schirmaier F and Philippsen P (1984) Identification of two genes coding for the translation elongation factor EF-1 alpha of S. cerevisiae. EMBO J 3(13):3311-5
2)	Murthi A, et al. (2009) Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in S. cerevisiae. Mol Biol Cell ()

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