TDP1/YBR223C Summary Help

Standard Name TDP1 1
Systematic Name YBR223C
Feature Type ORF, Verified
Description Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI (1, 2, 3)
Name Description Tyrosyl-DNA Phosphodiesterase 1
Chromosomal Location
ChrII:670297 to 668663 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TDP1 GO evidence and references
  View Computational GO annotations for TDP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
62 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 2
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 9
  • Phenotypic Enhancement: 20
  • Positive Genetic: 1
  • Synthetic Growth Defect: 17
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 544
Molecular Weight (Da) 62,333
Isoelectric Point (pI) 8.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:670297 to 668663 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YBR223W-A
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1635 670297..668663 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000427
References cited on this page View Complete Literature Guide for TDP1
1) Pouliot JJ, et al.  (1999) Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286(5439):552-5
2) Nitiss KC, et al.  (2006) Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci U S A 103(24):8953-8
3) He X, et al.  (2007) Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison. J Mol Biol 372(4):1070-81