TDA5/YLR426W Summary Help

Standard Name TDA5 1
Systematic Name YLR426W
Feature Type ORF, Uncharacterized
Description Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele (1, 2, 3, 4)
Name Description Topoisomerase I Damage Affected 1
Chromosomal Location
ChrXII:987062 to 988113 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TDA5 GO evidence and references
  View Computational GO annotations for TDA5
Molecular Function
Manually curated
Biological Process
High-throughput
Cellular Component
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
23 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Co-purification: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 12
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 326
Molecular Weight (Da) 36,676
Isoelectric Point (pI) 9.17
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:987062 to 988113 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..80 987062..987141 2011-02-03 1996-07-31
Intron 81..151 987142..987212 2011-02-03 1996-07-31
CDS 152..1052 987213..988113 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004418
References cited on this page View Complete Literature Guide for TDA5
1) Reid RJ, et al.  (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86
2) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
3) Lee W, et al.  (2005) Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS Genet 1(2):e24
4) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54