TDA10/YGR205W Summary Help

Standard Name TDA10 1
Systematic Name YGR205W
Feature Type ORF, Verified
Description ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele (1, 2)
Name Description Topoisomerase I Damage Affected 1
Chromosomal Location
ChrVII:909213 to 910085 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TDA10 GO evidence and references
  View Computational GO annotations for TDA10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Large-scale survey
null
Resources
11 total interaction(s) for 10 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 5
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:909213 to 910085 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..873 909213..910085 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003437
References cited on this page View Complete Literature Guide for TDA10
1) Reid RJ, et al.  (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86
2) de La Sierra-Gallay IL, et al.  (2004) Crystal structure of the YGR205w protein from Saccharomyces cerevisiae: close structural resemblance to E. coli pantothenate kinase. Proteins 54(4):776-83