TCO89/YPL180W Summary 
| Standard Name | TCO89 |
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| Systematic Name | YPL180W |
| Feature Type | ORF, Verified |
| Description | Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin (1 and see Summary Paragraph) |
| Name Description | Tor Complex One 1 |
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| View Computational GO annotations for TCO89 | |
| Molecular Function | |
| Manually curated |
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| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
| 230 total interaction(s) for 174 unique genes/features. | |
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| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
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| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000006101 |
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TCO89 encodes a nonessential protein that is a component of the TOR complex 1 (TORC1; 1). TORC1 mediates cell growth in response to nutrient availability and cellular stresses by regulating protein synthesis, ribosome biogenesis, autophagy, meiosis, cell cycling, nutrient permease sorting and turnover, and transcriptional activation (2, 3, 4, 5, 6, 7, 2, 8, 9, 10). However, for transcriptional regulation, the presence of Tco89p in TORC1 appears to be dispensable (1). In addition to Tco89p, TORC1 consists of Lst8p, Kog1p, and either Tor1p or Tor2p (3, 1). Mutations in TCO89 are synthetically lethal in combination with tor1 mutations and loss of Tco89p leads to rapamycin hypersensitivity and defects in cell wall integrity (1). Similarly to Tor1p, Tor2p, and Lst8p, Tco89p localizes to the inner side of the plasma membrane, but unlike the other TORC1 components Tco89p can also be found surrounding the vacuolar membrane. This distinct pattern of localization suggests that Tco89p may have an additional function separate from its role as a component of TORC1 (1).
Last updated: 2005-11-03 
| 1) | Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 |
| 2) | Cardenas ME, et al. (1999) The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev 13(24):3271-9 |
| 3) | Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68 |
| 4) | Weisman R and Choder M (2001) The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine. J Biol Chem 276(10):7027-32 |
| 5) | Barbet NC, et al. (1996) TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7(1):25-42 |
| 6) | Powers T and Walter P (1999) Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol Biol Cell 10(4):987-1000 |
| 7) | Kamada Y, et al. (2000) Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150(6):1507-13 |
| 8) | Zheng XF and Schreiber SL (1997) Target of rapamycin proteins and their kinase activities are required for meiosis. Proc Natl Acad Sci U S A 94(7):3070-5 |
| 9) | Heitman J, et al. (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253(5022):905-9 |
| 10) | Schmidt A, et al. (1998) The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J 17(23):6924-31 |
