TAX4/YJL083W Summary Help

Standard Name TAX4 1
Systematic Name YJL083W
Feature Type ORF, Verified
Description EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication (1, 2, 3, 4)
Chromosomal Location
ChrX:278841 to 280655 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TAX4 GO evidence and references
  View Computational GO annotations for TAX4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Large-scale survey
null
Resources
31 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 13
  • Phenotypic Enhancement: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 604
Molecular Weight (Da) 68,767
Isoelectric Point (pI) 10.47
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:278841 to 280655 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1815 278841..280655 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003619
References cited on this page View Complete Literature Guide for TAX4
1) Morales-Johansson H, et al.  (2004) Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4. J Biol Chem 279(38):39604-10
2) Paoluzi S, et al.  (1998) Recognition specificity of individual EH domains of mammals and yeast. EMBO J 17(22):6541-50
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Bugnicourt A, et al.  (2008) Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Traffic 9(5):755-69