TAT2/YOL020W Summary Help

Standard Name TAT2 1
Systematic Name YOL020W
Alias LTG3 , SAB2 , SCM2 , TAP2 2
Feature Type ORF, Verified
Description High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance (1, 2, 3, 4)
Name Description Tryptophan Amino acid Transporter 1
Chromosomal Location
ChrXV:286172 to 287950 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TAT2 GO evidence and references
  View Computational GO annotations for TAT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
67 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Co-fractionation: 1
  • Co-localization: 1
  • PCA: 5
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 2
  • Dosage Rescue: 9
  • Negative Genetic: 19
  • Phenotypic Suppression: 5
  • Positive Genetic: 9
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 592
Molecular Weight (Da) 65,404
Isoelectric Point (pI) 8.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:286172 to 287950 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1779 286172..287950 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000005380
References cited on this page View Complete Literature Guide for TAT2
1) Schmidt A, et al.  (1994) Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Mol Cell Biol 14(10):6597-606
2) Heitman J, et al.  (1993) The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. Mol Cell Biol 13(8):5010-9
3) Regenberg B, et al.  (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28
4) Welsch CA, et al.  (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82