Standard Name	TAH18 1
Systematic Name	YPR048W
Feature Type	ORF, Verified
Description	Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance (2, 3, 4)
Name Description	Top1T722A mutant Hypersensitive 1

Chromosomal Location	ChrXVI:659182 to 661053 | ORF Map | GBrowse

	View Computational GO annotations for TAH18
Molecular Function
Manually curated	oxidoreductase activity, acting on NAD(P)H (IDA)
Biological Process
Manually curated	iron-sulfur cluster assembly (IMP) nitric oxide biosynthetic process (IMP) oxidation-reduction process (IDA)
Cellular Component
Manually curated	mitochondrion (IDA)

Classical genetics
conditional	heat sensitivity: increased resistance to hydrogen peroxide: increased
overexpression	resistance to hydrogen peroxide: decreased
reduction of function	heat sensitivity: increased resistance to hydrogen peroxide: increased vegetative growth: decreased
repressible	Leu1p modification: decreased
Large-scale survey
null	inviable
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	22 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 2 Biochemical Activity: 1 PCA: 3 Reconstituted Complex: 1 Two-hybrid: 8
Genetic Interactions	Dosage Rescue: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:659182 to 661053 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1872 659182..661053 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006252