TAH18/YPR048W Summary Help

Standard Name TAH18 1
Systematic Name YPR048W
Feature Type ORF, Verified
Description Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs (2, 3, 4)
Name Description Top1T722A mutant Hypersensitive 1
Chromosomal Location
ChrXVI:659182 to 661053 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TAH18 GO evidence and references
  View Computational GO annotations for TAH18
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
overexpression
reduction of function
repressible
Large-scale survey
null
reduction of function
Resources
26 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 5
  • Biochemical Activity: 1
  • PCA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Rescue: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 623
Molecular Weight (Da) 72,327
Isoelectric Point (pI) 8.78
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:659182 to 661053 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1872 659182..661053 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006252
References cited on this page View Complete Literature Guide for TAH18
1) Reid, R., et al.  (1998) In preparation
2) Vernis L, et al.  (2009) A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast. PLoS One 4(2):e4376
3) Netz DJ, et al.  (2010) Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol 6(10):758-65
4) Nishimura A, et al.  (2013) The flavoprotein Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells. Biochem Biophys Res Commun 430(1):137-43