TAE2/YPL009C Summary Help

Standard Name TAE2 1
Systematic Name YPL009C
Feature Type ORF, Verified
Description Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Tae2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation involved in protein translation; monitors translation stress and signals this to Hsf1p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm (1, 2, 3, 4)
Name Description Translation Associated Element 1
Chromosomal Location
ChrXVI:538936 to 535820 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TAE2 GO evidence and references
  View Computational GO annotations for TAE2
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
100 total interaction(s) for 86 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 29
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 2
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 20
  • Negative Genetic: 3
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 31
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,038
Molecular Weight (Da) 119,068
Isoelectric Point (pI) 5.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:538936 to 535820 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3117 538936..535820 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005930
References cited on this page View Complete Literature Guide for TAE2
1) Alamgir M, et al.  (2010) Chemical-genetic profile analysis of five inhibitory compounds in yeast. BMC Chem Biol 10():6
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Fleischer TC, et al.  (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
4) Brandman O, et al.  (2012) A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell 151(5):1042-54