SUS1/YBR111W-A Summary Help

Standard Name SUS1 1
Systematic Name YBR111W-A
Feature Type ORF, Verified
Description Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP (1, 2, 3, 4, 5, 6, 7)
Name Description Sl gene Upstream of ySa1 1
Chromosomal Location
ChrII:462139 to 462579 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SUS1 GO evidence and references
  View Computational GO annotations for SUS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 42 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
466 total interaction(s) for 302 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 182
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 47
  • Biochemical Activity: 4
  • Co-crystal Structure: 1
  • PCA: 2
  • Reconstituted Complex: 4

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 174
  • Phenotypic Enhancement: 1
  • Positive Genetic: 33
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 8
  • Synthetic Rescue: 2

Resources
Length (a.a.) 96
Molecular Weight (Da) 11,084
Isoelectric Point (pI) 4.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:462139 to 462579 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-12-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..71 462139..462209 2011-02-03 2003-12-17
Intron 72..151 462210..462289 2011-02-03 2003-12-17
CDS 152..291 462290..462429 2011-02-03 2003-12-17
Intron 292..361 462430..462499 2011-02-03 2003-12-17
CDS 362..441 462500..462579 2011-02-03 2003-12-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000028510
References cited on this page View Complete Literature Guide for SUS1
1) Rodriguez-Navarro S, et al.  (2004) Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell 116(1):75-86
2) Cabal GG, et al.  (2006) SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope. Nature 441(7094):770-3
3) Kohler A, et al.  (2006) The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11. Mol Biol Cell 17(10):4228-36
4) Gonzalez-Aguilera C, et al.  (2008) The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability. Mol Biol Cell 19(10):4310-8
5) Pascual-Garcia P, et al.  (2008) Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2. Genes Dev 22(20):2811-22
6) Chekanova JA, et al.  (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14(1):66-77
7) Tous C, et al.  (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64