Standard Name	SUS1 1
Systematic Name	YBR111W-A
Feature Type	ORF, Verified
Description	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP (1, 2, 3, 4, 5, 6, 7)
Name Description	Sl gene Upstream of ySa1 1

Chromosomal Location	ChrII:462139 to 462579 | ORF Map | GBrowse

	View Computational GO annotations for SUS1
Molecular Function
Manually curated	enzyme activator activity (IDA)
Biological Process
Manually curated	histone deubiquitination (IMP) histone H3-K4 methylation (IMP) histone H3-K79 methylation (IMP) nuclear retention of pre-mRNA at the site of transcription (IMP) poly(A)+ mRNA export from nucleus (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP, IPI) posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery (IMP) regulation of protein localization (IMP) transcription elongation from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	DUBm complex (IDA) nuclear pore (IDA) nucleoplasm (IDA) SAGA complex (IDA) transcription export complex 2 (IDA)

Classical genetics
null	heat sensitivity: increased mitotic recombination: increased nuclear export: decreased Sac3p-GFP distribution: abnormal Histone H2B modification: increased viable
Large-scale survey
null	heat sensitivity: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	457 total interaction(s) for 303 unique genes/features.
Physical Interactions	Affinity Capture-MS: 179 Affinity Capture-RNA: 2 Affinity Capture-Western: 45 Biochemical Activity: 4 Co-crystal Structure: 1 PCA: 2 Reconstituted Complex: 4
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 174 Positive Genetic: 33 Synthetic Growth Defect: 4 Synthetic Lethality: 6 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:462139 to 462579 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-12-17
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..71 462139..462209 2011-02-03 2003-12-17 Intron 72..151 462210..462289 2011-02-03 2003-12-17 CDS 152..291 462290..462429 2011-02-03 2003-12-17 Intron 292..361 462430..462499 2011-02-03 2003-12-17 CDS 362..441 462500..462579 2011-02-03 2003-12-17
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (72 - 151) Intron (292 - 361)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000028510