SEC66/YBR171W Summary Help

Standard Name SEC66
Systematic Name YBR171W
Alias HSS1 , SEC71
Feature Type ORF, Verified
Description Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec63p, Sec62p, and Sec72p (1)
Name Description SECretory
Chromosomal Location
ChrII:578364 to 578984 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SEC66 GO evidence and references
  View Computational GO annotations for SEC66
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
697 total interaction(s) for 350 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 8
  • Co-fractionation: 1
  • Co-purification: 5
  • PCA: 8
  • Reconstituted Complex: 6
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 479
  • Phenotypic Enhancement: 23
  • Phenotypic Suppression: 59
  • Positive Genetic: 50
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 19

Resources
Expression Summary
histogram
Resources
Length (a.a.) 206
Molecular Weight (Da) 24,231
Isoelectric Point (pI) 7.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:578364 to 578984 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..621 578364..578984 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000375
References cited on this page View Complete Literature Guide for SEC66
1) Young BP, et al.  (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71