SEC62/YPL094C Summary Help

Standard Name SEC62 1
Systematic Name YPL094C
Alias LPG14
Feature Type ORF, Verified
Description Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec62p, Sec66p and Sec72p (2, 3, 4, 5)
Name Description SECretory
Chromosomal Location
ChrXVI:370663 to 369839 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SEC62 GO evidence and references
  View Computational GO annotations for SEC62
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Classical genetics
unspecified
Large-scale survey
null
overexpression
reduction of function
Resources
172 total interaction(s) for 86 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 13
  • Biochemical Activity: 1
  • Co-purification: 3
  • PCA: 9
  • Two-hybrid: 30

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 72
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 2
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 274
Molecular Weight (Da) 31,346
Isoelectric Point (pI) 10.55
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:370663 to 369839 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2004-01-09
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..825 370663..369839 2011-02-03 2004-01-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006015
References cited on this page View Complete Literature Guide for SEC62
1) Rothblatt JA, et al.  (1989) Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast. J Cell Biol 109(6 Pt 1):2641-52
2) Deshaies RJ and Schekman R  (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64
3) Young BP, et al.  (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71
4) Willer M, et al.  (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48
5) Soromani C, et al.  (2012) N-acetylation and phosphorylation of Sec complex subunits in the ER membrane. BMC Cell Biol 13(1):34