SWT1/YOR166C Summary Help

Standard Name SWT1 1
Systematic Name YOR166C
Feature Type ORF, Verified
Description RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain (1, 2, 3)
Name Description Synthetically lethal With Trex 1
Chromosomal Location
ChrXV:648502 to 647126 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SWT1 GO evidence and references
  View Computational GO annotations for SWT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 43 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
unspecified
Resources
35 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Co-localization: 1

Genetic Interactions
  • Negative Genetic: 8
  • Phenotypic Enhancement: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 16

Resources
Expression Summary
histogram
Resources
Length (a.a.) 458
Molecular Weight (Da) 52,373
Isoelectric Point (pI) 5.07
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:648502 to 647126 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1377 648502..647126 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005692
References cited on this page View Complete Literature Guide for SWT1
1) Rother S, et al.  (2006) Swt1, a novel yeast protein, functions in transcription. J Biol Chem 281(48):36518-25
2) Bleichert F, et al.  (2006) The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Proc Natl Acad Sci U S A 103(25):9464-9
3) Skruzny M, et al.  (2009) An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. PLoS Biol 7(1):e8