Standard Name	SWR1
Systematic Name	YDR334W
Feature Type	ORF, Verified
Description	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4)
Name Description	Sick With Rat8 ts

Chromosomal Location	ChrIV:1135932 to 1140476 | ORF Map | GBrowse

	View Computational GO annotations for SWR1
Molecular Function
Manually curated	structural molecule activity (IMP)
Biological Process
Manually curated	chromatin remodeling (IDA, IMP) histone exchange (IMP)
High-throughput	chromatin remodeling (IGI)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA) Swr1 complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	tellurium atom accumulation: decreased resistance to hydroxyurea: decreased resistance to tellurite: increased resistance to benomyl: decreased viable
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased metal resistance: decreased protein transport: abnormal resistance to wortmannin: normal resistance to flubendazole: decreased resistance to dimethyl sulfoxide: decreased resistance to sodium selenide: decreased resistance to fenpropimorph: decreased resistance to caffeine: decreased resistance to bleomycin: decreased resistance to oleate: decreased resistance to sirolimus: decreased resistance to hydroxyurea: increased resistance to camptothecin: increased resistance to cycloheximide: decreased resistance to paromomycin: decreased resistance to benomyl: decreased resistance to sodium arsenite: decreased starvation resistance: decreased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	1065 total interaction(s) for 396 unique genes/features.
Physical Interactions	Affinity Capture-MS: 87 Affinity Capture-Western: 47 Co-fractionation: 1 Co-localization: 2 PCA: 1 Reconstituted Complex: 2
Genetic Interactions	Negative Genetic: 561 Phenotypic Enhancement: 12 Phenotypic Suppression: 5 Positive Genetic: 66 Synthetic Growth Defect: 137 Synthetic Lethality: 80 Synthetic Rescue: 64
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1135932 to 1140476 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4545 1135932..1140476 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002742