SWR1/YDR334W Summary Help

Standard Name SWR1
Systematic Name YDR334W
Feature Type ORF, Verified
Description Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction (1, 2, 3, 4, 5)
Name Description Sick With Rat8 ts
Chromosomal Location
ChrIV:1135932 to 1140476 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SWR1 GO evidence and references
  View Computational GO annotations for SWR1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
1089 total interaction(s) for 402 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 90
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 47
  • Co-fractionation: 1
  • Co-localization: 4
  • Co-purification: 11
  • PCA: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Negative Genetic: 561
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 6
  • Positive Genetic: 66
  • Synthetic Growth Defect: 139
  • Synthetic Lethality: 81
  • Synthetic Rescue: 65

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,514
Molecular Weight (Da) 174,529
Isoelectric Point (pI) 6.17
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1135932 to 1140476 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4545 1135932..1140476 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002742
References cited on this page View Complete Literature Guide for SWR1
1) Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76
2) Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8
3) Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71
4) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
5) Garay E, et al.  (2014) High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions. PLoS Genet 10(2):e1004168