SWM2/YNR004W Summary Help

Standard Name SWM2 1
Systematic Name YNR004W
Feature Type ORF, Verified
Description Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p (2, 3)
Name Description Synthetic With mud2-delta 1
Chromosomal Location
ChrXIV:635943 to 636383 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SWM2 GO evidence and references
  View Computational GO annotations for SWM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
69 total interaction(s) for 60 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Co-localization: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 43
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 11
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 146
Molecular Weight (Da) 17,096
Isoelectric Point (pI) 5.17
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:635943 to 636383 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..441 635943..636383 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005287
References cited on this page View Complete Literature Guide for SWM2
1) Chang J, et al.  (2010) Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: Proteins implicated in pre-mRNA splicing. RNA 16(5):1018-31
2) Volckaert G, et al.  (2003) Disruption of 12 ORFs located on chromosomes IV, VII and XIV of Saccharomyces cerevisiae reveals two essential genes. Yeast 20(1):79-88
3) Boon KL and Kos M  (2010) Deletion of Swm2p selectively impairs trimethylation of snRNAs by trimethylguanosine synthase (Tgs1p). FEBS Lett 584(15):3299-304