SWM1/YDR260C Summary Help

Standard Name SWM1 1
Systematic Name YDR260C
Alias APC13 2
Feature Type ORF, Verified
Description Subunit of the anaphase-promoting complex (APC); APC is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation (1, 2, 3, 4)
Name Description Spore Wall Maturation 1
Chromosomal Location
ChrIV:977229 to 976717 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SWM1 GO evidence and references
  View Computational GO annotations for SWM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
195 total interaction(s) for 94 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 68
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 3
  • Co-fractionation: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 67
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 26
  • Synthetic Lethality: 11
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 170
Molecular Weight (Da) 19,356
Isoelectric Point (pI) 4.96
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:977229 to 976717 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..513 977229..976717 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002668
References cited on this page View Complete Literature Guide for SWM1
1) Ufano S, et al.  (1999) SWM1, a developmentally regulated gene, is required for spore wall assembly in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2118-29
2) Hall MC, et al.  (2003) Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. J Biol Chem 278(19):16698-705
3) Ufano S, et al.  (2004) Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae. J Cell Sci 117(Pt 4):545-57
4) Ufano S, et al.  (2004) Swm1p, a subunit of the APC/cyclosome, is required to maintain cell wall integrity during growth at high temperature in Saccharomyces cerevisiae. FEMS Microbiol Lett 234(2):371-8