SWI6/YLR182W Summary Help

Standard Name SWI6 1
Systematic Name YLR182W
Alias PSL8 , SDS11 2
Feature Type ORF, Verified
Description Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators (3, 4, 5, 6, 7, 8)
Name Description SWItching deficient 1
Chromosomal Location
ChrXII:517940 to 520351 | ORF Map | GBrowse
Gene Ontology Annotations All SWI6 GO evidence and references
  View Computational GO annotations for SWI6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 141 genes
Classical genetics
reduction of function
Large-scale survey
583 total interaction(s) for 392 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 36
  • Biochemical Activity: 9
  • Co-purification: 1
  • PCA: 6
  • Protein-peptide: 1
  • Reconstituted Complex: 9
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Growth Defect: 4
  • Dosage Rescue: 19
  • Negative Genetic: 210
  • Phenotypic Enhancement: 11
  • Phenotypic Suppression: 16
  • Positive Genetic: 97
  • Synthetic Growth Defect: 69
  • Synthetic Lethality: 53
  • Synthetic Rescue: 10

Expression Summary
Length (a.a.) 803
Molecular Weight (Da) 90,559
Isoelectric Point (pI) 4.58
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXII:517940 to 520351 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2412 517940..520351 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004172
References cited on this page View Complete Literature Guide for SWI6
1) Breeden L and Nasmyth K  (1987) Cell cycle control of the yeast HO gene: cis- and trans-acting regulators. Cell 48(3):389-97
2) Sussel L, et al.  (1995) Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics 141(3):873-88
3) Leem SH, et al.  (1998) Meiotic role of SWI6 in Saccharomyces cerevisiae. Nucleic Acids Res 26(13):3154-8
4) Ho Y, et al.  (1999) Regulation of transcription at the Saccharomyces cerevisiae start transition by Stb1, a Swi6-binding protein. Mol Cell Biol 19(8):5267-78
5) Sidorova JM, et al.  (1995) Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization. Mol Biol Cell 6(12):1641-58
6) Horak CE, et al.  (2002) Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev 16(23):3017-33
7) Scrimale T, et al.  (2009) The Unfolded Protein Response Is Induced by the Cell Wall Integrity Mitogen-activated Protein Kinase Signaling Cascade and Is Required for Cell Wall Integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(1):164-75
8) Kim KY, et al.  (2010) Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell 21(9):1609-19
9) Taba MR, et al.  (1991) Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast. Genes Dev 5(11):2000-13
10) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104